Basic Information
| LncRNA/CircRNA Name | MAGI2-AS3 |
| Synonyms | NA |
| Region | GRCh38_7:79452877-79471208 |
| Ensemble | ENSG00000234456 |
| Refseq | NR_038343 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | high grade ovarian serous cancer |
| ICD-0-3 | C56 |
| Methods | RNA-seq, qRT-PCR |
| Sample | ovarian cancer cell lines PEA1, PEA2, PEO14, and PEO23 |
| Expression Pattern | down-regulated |
| Function Description | MAGI2-AS3 acts as a tumor suppressor in EOC, specifically in HGSC by sponging miR-15-5p, miR-374a-5p and miR-374b-5p, and altering downstream signaling of certain mRNAs through a ceRNA network. |
| Pubmed ID | 31842477 |
| Year | 2019 |
| Title | Long Non-Coding RNA MAGI2-AS3 Is a New Player With a Tumor Suppressive Role in High Grade Serous Ovarian Carcinoma |
External Links
| Links for MAGI2-AS3 | GenBank HGNC NONCODE |
| Links for high grade ovarian serous cancer | OMIM COSMIC |