Basic Information
| LncRNA/CircRNA Name | MAFG-AS1 |
| Synonyms | NA |
| Region | GRCh38_17:81927829-81930753 |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | hepatocellular carcinoma |
| ICD-0-3 | C22.0 |
| Methods | qRT-PCR, Western blotting, in vitro knockdown etc. |
| Sample | human HCC cells (Hep3B and Huh7) and a human liver cell line (L02) |
| Expression Pattern | up-regulated |
| Function Description | LncRNA MAFG-AS1 expression was increased in HCC tissues and cell lines. Following knockdown of lncRNA MAFG-AS1, a Cell Counting Kit-8 assay and Transwell assay demonstrated that the proliferation, migration and invasion of HCC cell lines were significantly inhibited. It was additionally demonstrated that there was a negative regulatory association between lncRNA MAFG-AS1 and miR-6852. Inhibition of miR-6852 increased proliferation, migration and invasion of HCC cell lines. |
| Pubmed ID | 31572506 |
| Year | 2019 |
| Title | Long Noncoding RNA MAFG-AS1 Promotes Proliferation, Migration and Invasion of Hepatocellular Carcinoma Cells Through Downregulation of miR-6852 |
External Links
| Links for MAFG-AS1 | GenBank HGNC NONCODE |
| Links for hepatocellular carcinoma | OMIM COSMIC |