Basic Information
| LncRNA/CircRNA Name | MACC1-AS1 |
| Synonyms | NA |
| Region | GRCh38_7:20141916-20153531 |
| Ensemble | ENSG00000228598 |
| Refseq | NR_046756 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | nasopharyngeal cancer |
| ICD-0-3 | C11 |
| Methods | qPCR, Western blot |
| Sample | NPC tissues,NPC tissues |
| Expression Pattern | up-regulated |
| Function Description | smad2 directly bound to MACC1-AS1 promoter and thus increased MACC1-AS1 expression. Notably, knockdown of miR-145 or overexpression of Smad2 rescued the inhibition of MACC1-AS1 knockdown on the stemness of NPC cells. |
| Pubmed ID | 32058221 |
| Year | 2020 |
| Title | The long non-coding RNA MACC1-AS1 promotes nasopharyngeal carcinoma cell stemness via suppressing miR-145-mediated inhibition on SMAD2/MACC1-AS1 axis |
External Links
| Links for MACC1-AS1 | GenBank HGNC NONCODE |
| Links for nasopharyngeal cancer | OMIM COSMIC |