Basic Information
| LncRNA/CircRNA Name | MACC1-AS1 |
| Synonyms | NA |
| Region | GRCh38_7:20141916-20153531 |
| Ensemble | ENSG00000228598 |
| Refseq | NR_046756 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | 2 | ||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | lung adenocarcinoma |
| ICD-0-3 | C34 |
| Methods | qPCR, Western blot |
| Sample | LUAD tissues,cell lines |
| Expression Pattern | up-regulated |
| Function Description | In LUAD cells, overexpression of MACC1-AS1 led to decreased expression of PTEN and increased proliferation rate of LUAD cells, while MACC1-AS1 silencing led to increased expression of PTEN and decreased proliferation rate of LUAD cells.MACC1-AS1 promoted cell proliferation by down-regulating PTEN in LUAD cells. |
| Pubmed ID | 32109147 |
| Year | 2020 |
| Title | LncRNA MACC1-AS1 Promotes Lung Adenocarcinoma Cell Proliferation by Downregulating PTEN |
External Links
| Links for MACC1-AS1 | GenBank HGNC NONCODE |
| Links for lung adenocarcinoma | OMIM COSMIC |