Basic Information
| LncRNA/CircRNA Name | LUNAR1 |
| Synonyms | NA |
| Region | GRCh38_1:29554-31109 |
| Ensemble | |
| Refseq | NR_126487 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colorectal cancer |
| ICD-0-3 | C19.9 |
| Methods | RT-PCR |
| Sample | CRC specimens,Colorectal cancer cell lines HT29, SW480 and SW620 |
| Expression Pattern | up-regulated |
| Function Description | Significantly increased expression of LUNAR1 in clinical CRC specimens was detected compared with that in matching normal tissues. LUNAR1 expression in CRC was found to be associated with the tumour aggressiveness, disease-free survival and overall survival of patients. The downregulation of LUNAR1 in SW620 cells inhibited cell proliferation, migration, invasion and tumour growth while inducing apoptosis. Moreover, the inhibition of LUNAR1 can significantly suppress IGF1 signalling in CRC. |
| Pubmed ID | 31882986 |
| Year | 2019 |
| Title | The Novel Notch-induced Long Noncoding RNA LUNAR1 Determines the Proliferation and Prognosis of Colorectal Cancer |
External Links
| Links for LUNAR1 | GenBank HGNC NONCODE |
| Links for colorectal cancer | OMIM COSMIC |