Basic Information
| LncRNA/CircRNA Name | Lucat1 |
| Synonyms | LUCAT1, SCAL1 |
| Region | GRCh38_5:91303029-91314402 |
| Ensemble | ENSG00000248323 |
| Refseq | NR_103548 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | clear cell renal cell carcinoma |
| ICD-0-3 | C64.9 |
| Methods | RNA-seq, RIP |
| Sample | renal cancer cell lines, renal cancer tissues |
| Expression Pattern | up-regulated |
| Function Description | We screened the lncRNAs??profile in ccRCC from The Cancer Genome Atlas (TCGA) database, and selected Lucat1 for further study. MTS, colony formation assay and transwell assay were performed to examine the effect of Lucat1 on proliferation and metastasis of ccRCC. The Chip and Rip assay was performed to verify that Lucat1 can bind to polycomb PRC2 complex and suppress p57 expression.PRC2, a methyltransferase that is composed of enhancer of zeste homolog 2 (EZH2), suppressor of zeste 12 (SUZ12) and embryonic ectoderm development (EED), can catalyze the di- and trimethylation of lysine residue 27 of histone 3 (H3K27me3), thus modulating gene expression. Kaplan-Meier analysis indicated that high Lucat1 expression was related to a poorer overall survival and disease free survival. |
| Pubmed ID | 29371934 |
| Year | 2017 |
| Title | Long non-coding RNA Lucat1 is a poor prognostic factor and demonstrates malignant biological behavior in clear cell renal cell carcinoma. |
External Links
| Links for Lucat1 | GenBank HGNC NONCODE |
| Links for clear cell renal cell carcinoma | OMIM COSMIC |