Basic Information
| LncRNA/CircRNA Name | LUCAT1 |
| Synonyms | NA |
| Region | GRCh38_5:91303029-91314402 |
| Ensemble | ENSG00000248323 |
| Refseq | NR_103548 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | breast cancer |
| ICD-0-3 | C50 |
| Methods | Microarray, qPCR, Western blot, Luciferase reporter assay, RIP |
| Sample | Normal breast epithelial cell line MCF-10A, breast cancer cell lines MCF-7 and T47D, Fresh cancer tissues and the matched adjacent normal tissues |
| Expression Pattern | up-regulated |
| Function Description | LUCAT1 expression was related to tumor size (p = 0.015), lymph node metastasis (p = 0.002) and TNM staging (p < 0.001). High LUCAT1 expression indicated a shorter overall survival (p = 0.006) and disease-free survival (p = 0.011). Furthermore, LUCAT1 was more expressed in BCSCs than in breast cancer cells (BCCs) by lncRNA microarray chips. LUCAT1 up-regulation promoted proliferation of BCCs, while LUCAT1 downregulation inhibited self-renewal of BCSCs. MiR-5582-3p was directly bound to LUCAT1 and TCF7L2 and negatively regulated their expression. LUCAT1 affected Wnt/?-catenin pathway. |
| Pubmed ID | 31300015 |
| Year | 2019 |
| Title | Long non-coding RNA LUCAT1/miR-5582- 3p/TCF7L2 axis regulates breast cancer stemness via Wnt/?-catenin pathway |
External Links
| Links for LUCAT1 | GenBank HGNC NONCODE |
| Links for breast cancer | OMIM COSMIC |