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Basic Information

Classification Information

Regulatory Mechanism		Biological Function		Clinical Application
TF		Immune		Survival
Enhancer		Apoptosis		Drug
Variant		Cell Growth		Circulating
MiRNA		EMT		Metastasis
Methylation		Coding Ability		Recurrence

Cancer&Entry Information

Cancer Name	cervical cancer
ICD-0-3	C53
Methods	qPCR, Western blot, etc.
Sample	cervical cancer tissues, cervical cancer cell lines SiHa, HeLa, Caski, C4-1 and C-33a, a normal cervical epithelium cell (NC104) and 293T cell
Expression Pattern	up-regulated
Function Description	By comparing with the expression level in corresponding ones, the LUCAT1 expression level in cervical cancer samples was significantly higher. Moreover, expression level of LUCAT1 was negatively correlated with patients overall survival time. In addition, after LUCAT1 was overexpressed, cell proliferation, cell invasion and migration capacities were promoted in vitro. In addition, the mRNA and protein expressions of MTA1 were upregulated after LUCAT1 was overexpressed. Furthermore, it was found that the expression level of MTA1 was positively related to LUCAT1 expression level in cervical cancer tissues. CONCLUSIONS: We showed that LUCAT1 could enhance proliferation, invasion and migration of cervical cancer cells through upregulating MTA1
Pubmed ID	31486481
Year	2019
Title	Long noncoding RNA LUCAT1 promotes cervical cancer cell proliferation and invasion by upregulating MTA1

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