Basic Information
| LncRNA/CircRNA Name | LUCAT1 |
| Synonyms | NA |
| Region | GRCh38_5:91303029-91314402 |
| Ensemble | ENSG00000248323 |
| Refseq | NR_103548 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | hepatoblastoma |
| ICD-0-3 | C22.0 |
| Methods | qPCR, Western blot, Luciferase reporter assay, RIP, etc. |
| Sample | hepatoblastoma tissues, Tumor cell lines (HepG2, HuH-6, and SMMC-7221) and normal human hepatocytes (L-02) |
| Expression Pattern | up-regulated |
| Function Description | LUCAT1 was highly expressed in hepatoblastoma tissues and cell lines. To identify the biological function of LUCAT1 in hepatoblastoma, loss-of function assays were carried out. Knockdown of LUCAT1 inhibited cell proliferation, migration and invasion but reversed epithelial-mesenchymal transition (EMT) phenotype into MET. Next, we investigated the molecular mechanism of LUCAT1. STAT3 was found to be a transcription activator of LUCAT1. Further mechanism investigation revealed that LUCAT1 increased STAT3 expression through competitively binding to miR-301b. In conclusion, LUCAT1 was activated by STAT3 and promoted cell proliferation, migration and invasion in hepatoblastoma through modulating miR-301b/STAT3 axis. |
| Pubmed ID | 30479162 |
| Year | 2018 |
| Title | STAT3-activated lncRNA LUCAT1 drives cell proliferation, migration and invasion in hepatoblastoma through regulating miR301b/STAT3 axis |
External Links
| Links for LUCAT1 | GenBank HGNC NONCODE |
| Links for hepatoblastoma | OMIM COSMIC |