Basic Information
| LncRNA/CircRNA Name | LUCAT1 |
| Synonyms | NA |
| Region | GRCh38_5:91303029-91314402 |
| Ensemble | ENSG00000248323 |
| Refseq | NR_103548 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | macrophage | Survival | ||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | clear cell renal cell carcinoma |
| ICD-0-3 | C64.9 |
| Methods | Microarray, qPCR, Western blot |
| Sample | clear cell renal cell carcinoma tissues, cell lines (786-O, Caki-1, Caki-2, ACHN, 769-P, A-498) |
| Expression Pattern | up-regulated |
| Function Description | We found that LUCAT1 was significantly upregulated in both clinical ccRCC tissues (n = 90) and TCGA ccRCC tissues (n = 448) compared with normal tissues. Overall survival and disease-free survival time were significantly shorter in the high-LUCAT1-expression group than in the low-LUCAT1-expression group. Overexpression of LUCAT1 promoted proliferation, migration, and invasion of ccRCC cells. along with the above knockdown and overexpression experiments, indicated that CXCL2 in tumor microenvironments, synthesized and secreted by immune cells, induced LUCAT1 expression and promoted proliferation and invasion in ccRCC. |
| Pubmed ID | 30032137 |
| Year | 2018 |
| Title | Long Non-Coding RNA LUCAT1 Promotes Proliferation and Invasion in Clear Cell Renal Cell Carcinoma Through AKT/GSK-3? Signaling Pathway. |
External Links
| Links for LUCAT1 | GenBank HGNC NONCODE |
| Links for clear cell renal cell carcinoma | OMIM COSMIC |