Basic Information
| LncRNA/CircRNA Name | LUCAT1 |
| Synonyms | NA |
| Region | GRCh38_5:91303029-91314402 |
| Ensemble | ENSG00000248323 |
| Refseq | NR_103548 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | papillary thyroid cancer |
| ICD-0-3 | NA |
| Methods | qRT-PCR , Western blot , RIP , in vitro knockdown etc. |
| Sample | thyroid carcinoma tissues and their adjacent non-tumor tissues ,human papillary thyroid cancer cell lines (BCPAP, 8505c) , and TPC1 cell line |
| Expression Pattern | up-regulated |
| Function Description | In situ hybridization analysis using a specifc probe for LUCAT1 was performed in FFPE samples from the same PTC patients where LUCAT1 was found to be upregulated. LUCAT1 was specifically located at the cell nucleus in tumoral regions of patient tissues. Furthermore, LUCAT1 knockdown significantly reduced both cell proliferation and invasion ex vivo and induced cell-cycle arrest and apoptosis.Our study reveals the involvement of LUCAT1 in PTC development, through acting in cell-cycle regulation, proliferation, epigenetic modifications through LUCAT1/ CDK1/ EZH2/ P57/ P21/ HDAC1/ DNMT1/ P53/ BAX axis and apoptosis, via extrinsic pathway activating caspases. |
| Pubmed ID | 31591432 |
| Year | 2019 |
| Title | LncRNA LUCAT1 as a Novel Prognostic Biomarker for Patients With Papillary Thyroid Cancer |
External Links
| Links for LUCAT1 | GenBank HGNC NONCODE |
| Links for papillary thyroid cancer | OMIM COSMIC |