Basic Information
| LncRNA/CircRNA Name | lncRNA-ATB |
| Synonyms | LOC109207222 |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | cervical cancer |
| ICD-0-3 | C53 |
| Methods | qPCR, Luciferase reporter assay, Western blot |
| Sample | human cervical cancer cell lines |
| Expression Pattern | up-regulated |
| Function Description | We demonstrated that ITGA6 was a direct target of miR-144, and lncRNA ATB facilitated the proliferation and invasion of cervical cancer cells via the miR-144/ITGA5 axis. The association among lncRNA ATB, miR-144 and ITGA6 was disclosed by a dual-luciferase reporter assay. We found that lncRNA ATB was highly expressed in human cervical cancer cell lines. |
| Pubmed ID | 30908730 |
| Year | 2019 |
| Title | Long non-coding RNA activated by transforming growth factor-? promotes proliferation and invasion of cervical cancer cells by regulating the miR-144/ITGA6 axis. |
External Links
| Links for lncRNA-ATB | GenBank HGNC NONCODE |
| Links for cervical cancer | OMIM COSMIC |