Basic Information
| LncRNA/CircRNA Name | LUADT1 |
| Synonyms | LUCAT1, SCAL1 |
| Region | GRCh38_6:147158925-147180992 |
| Ensemble | ENSG00000196634 |
| Refseq | NR_132442 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | lung adenocarcinoma |
| ICD-0-3 | C34 |
| Methods | Microarray, qPCR, RNAi, Western blot, RIP, Flow cytometry assay etc. |
| Sample | lung cancer tissues, cell lines (A549, H1975, H358, H1650, H1299) |
| Expression Pattern | up-regulated |
| Function Description | LUADT1, which is highly expressed in LUAD and correlates with T stage, was characterized. LUADT1 knockdown significantly inhibited proliferation of LUAD cells and induced cell cycle arrest at the G0-G1 phase. Further analysis indicated that LUADT1 may regulate cell cycle progression by epigenetically inhibiting the expression of p27. RNA immunoprecipitation and chromatin immunoprecipitation assays confirmed that LUADT1 binds to SUZ12, a core component of polycomb repressive complex 2, and mediates the trimethylation of H3K27 at the promoter region of p27. |
| Pubmed ID | 26291312 |
| Year | 2015 |
| Title | A novel lncRNA, LUADT1, promotes lung adenocarcinoma proliferation via the epigenetic suppression of p27. |
External Links
| Links for LUADT1 | GenBank HGNC NONCODE |
| Links for lung adenocarcinoma | OMIM COSMIC |