Basic Information
| LncRNA/CircRNA Name | LSINCT5 |
| Synonyms | NA |
| Region | GRCh38_5:2712591-2715237 |
| Ensemble | |
| Refseq | NR_145480 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | non small cell lung cancer |
| ICD-0-3 | C34 |
| Methods | qPCR, Western blot, in vitro knockdown, RNAi, RIP |
| Sample | lung cancer tissues, cell lines (WI-38, A549, H1299, 95D, 95C and H838) |
| Expression Pattern | up-regulated |
| Function Description | LSINCT5 is overexpressed in NSCLC tissues with poor survival. In addition, the metastasis was also positively associated with LSINCT5 expression. LSINCT5 can promote migration and viability of various NSCLC cells in vitro and also enhance lung cancer progression in vivo. Ki-67 staining also confirmed that shLSINCT5 greatly obviated the proliferation of NSCLC xenograft tumors while LSINCT5 overexpression potentiated tumor growth. RNA immunoprecipitation followed by mass spectrometry has identified that LSINCT5 interacts with HMGA2. This physical interaction can increase the stability of HMGA2 by inhibiting proteasome-mediated degradation. |
| Pubmed ID | 29883241 |
| Year | 2018 |
| Title | The Long Non-Coding RNA LSINCT5 Promotes Malignancy in Non-Small Cell Lung Cancer by Stabilizing HMGA2 |
External Links
| Links for LSINCT5 | GenBank HGNC NONCODE |
| Links for non small cell lung cancer | OMIM COSMIC |