Basic Information
| LncRNA/CircRNA Name | LOXL1-AS1 |
| Synonyms | NA |
| Region | GRCh38_15:73908071-73928248 |
| Ensemble | ENSG00000261801 |
| Refseq | NR_040066 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | cholangiocarcinoma |
| ICD-0-3 | NA |
| Methods | qRT-PCR , Luciferase reporter assay , Western blot etc. |
| Sample | CCA specimens and normal tissues ,human CCA cell lines (RBE, HuCCT1, QBC939, Huh-28, and CCLP1) and HIBEC cells |
| Expression Pattern | up-regulated |
| Function Description | LOXL1-AS1 was found overexpressed in CCA tissues.Additionally, upregulation of LOXL1-AS1 was associated with lymph node invasion, advanced TNM stages and unfavorable prognosis.LOXL1-AS1 could facilitate cell proliferation, migration and invasion and attenuate cell apoptosis.LOXL1-AS1 functioned as a ceRNA to elevate ATP-binding cassette transporter A1 (ABCA1) level by sponging miR-324-3p and exhibited the malignant phenotypes of CCA cells, thereby playing an oncogenic role in CCA. |
| Pubmed ID | 31003776 |
| Year | 2019 |
| Title | Long Non-Coding RNA LOXL1-AS1 Acts as a ceRNA for miR-324-3p to Contribute to Cholangiocarcinoma Progression via Modulation of ATP-binding Cassette Transporter A1 |
External Links
| Links for LOXL1-AS1 | GenBank HGNC NONCODE |
| Links for cholangiocarcinoma | OMIM COSMIC |