Basic Information
| LncRNA/CircRNA Name | LOXL1-AS1 |
| Synonyms | NA |
| Region | GRCh38_15:73908071-73928248 |
| Ensemble | ENSG00000261801 |
| Refseq | NR_040066 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | breast cancer |
| ICD-0-3 | C50 |
| Methods | qRT-PCR, Western blot, Luciferase Reporter Assay |
| Sample | Breast cancer tissues,breast epithelial normal cells (HBL100) and breast cancer cell lines (MCF-7, MDA-MB-231, BT549 and SKBR-3) |
| Expression Pattern | up-regulated |
| Function Description | LOXL1-AS1 expression was induced while miR-142-3p expression was decreased in breast cancer tissues and cells, implying that LOXL1-AS1 and miR-143-3p play an important role in cell progression of breast cancer. Further investigation showed that silencing LOXL1-AS1 inhibited proliferation, promoted cell apoptosis and decreased the capacity of cell migrated and invasive in breast cancer cells. |
| Pubmed ID | 31841194 |
| Year | 2019 |
| Title | LncRNA LOXL1-AS1 Inhibited Cell Proliferation, Migration and Invasion as Well as Induced Apoptosis in Breast Cancer via Regulating miR-143-3p |
External Links
| Links for LOXL1-AS1 | GenBank HGNC NONCODE |
| Links for breast cancer | OMIM COSMIC |