Basic Information
| LncRNA/CircRNA Name | LOXL1-AS1 |
| Synonyms | NA |
| Region | GRCh38_15:73908071-73928248 |
| Ensemble | ENSG00000261801 |
| Refseq | NR_040066 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | breast cancer |
| ICD-0-3 | C50 |
| Methods | qPCR, Luciferase Reporter Assay, RIP, Western blot analysis |
| Sample | breast cancer cell lines (T47D, MCF7, MDA-MB-231, and MDA-MB-468 cells), as well as MCF10A nonmalignant breast epithelial cells,primary tumor specimens |
| Expression Pattern | up-regulated |
| Function Description | LOXL1-AS1 is upregulated in breast cancer tissues and cells compared to noncancerous counterparts. LOXL1-AS1 can interact with EZH2 protein to enhance EZH2-mediated transcriptional repression of miR-708-5p. Rescue experiments indicate that co-expression of miR-708-5p attenuates LOXL1-AS1-induced invasiveness in breast cancer. |
| Pubmed ID | 31945728 |
| Year | 2020 |
| Title | Long Non-coding RNA LOXL1-AS1 Drives Breast Cancer Invasion and Metastasis by Antagonizing miR-708-5p Expression and Activity |
External Links
| Links for LOXL1-AS1 | GenBank HGNC NONCODE |
| Links for breast cancer | OMIM COSMIC |