Basic Information
| LncRNA/CircRNA Name | LOC730101 |
| Synonyms | NA |
| Region | GRCh38_6:52664401-52669153 |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | osteosarcoma |
| ICD-0-3 | NA |
| Methods | qRT-PCR, Western blot, RNAi |
| Sample | tumor tissues, osteosarcoma cell lines (SAOS2, MG63, U2OS) |
| Expression Pattern | up-regulated |
| Function Description | compared with adjacent tissues, LOC730101 is remarkably increased in osteosarcoma in our fresh tissues. In addition, cellular function assays demonstrated that LOC730101 promotes cell viability, tumor development, and deficiency of LOC730101 promotes cell apoptosis under energy stress. Furthermore, we validated that up-regulated LOC730101 enhances cell viability through AMPK under energy stress. |
| Pubmed ID | 29253564 |
| Year | 2017 |
| Title | LncRNA LOC730101 promotes osteosarcoma cell survival under energy stress. |
External Links
| Links for LOC730101 | GenBank HGNC NONCODE |
| Links for osteosarcoma | OMIM COSMIC |