Basic Information
| LncRNA/CircRNA Name | LOC572558 |
| Synonyms | PGM5-AS1, FAM233A |
| Region | GRCh38_9:68355189-68357852 |
| Ensemble | ENSG00000224958 |
| Refseq | NR_015423 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | bladder cancer |
| ICD-0-3 | C67 |
| Methods | Microarray, qPCR, Western blot etc. |
| Sample | cell lines (T24 and 5637) |
| Expression Pattern | up-regulated |
| Function Description | We demonstrated that LOC572558 expression was markedly decreased in bladder cancer tissues and bladder cancer cell lines. Moreover, ectopic expression of LOC572558 inhibited cell proliferation and motility, induced S phase arrest of the cell cycle and promoted cell apoptosis in T24 and 5637 bladder cancer cell lines. We further verified that overexpression of LOC572558 was associated with dephosphorylation of AKT, MDM2 and phosphorylation of p53 protein. Our data clearly demonstrated that LOC572558 is a tumor suppressor and regulates the p53 signaling pathway in bladder cancer |
| Pubmed ID | 27130667 |
| Year | 2016 |
| Title | Long non-coding RNA LOC572558 inhibits bladder cancer cell proliferation and tumor growth by regulating the AKT-MDM2-p53 signaling axis |
External Links
| Links for LOC572558 | GenBank HGNC NONCODE |
| Links for bladder cancer | OMIM COSMIC |