Basic Information
| LncRNA/CircRNA Name | LOC554202 |
| Synonyms | MIR31HG, hsa-lnc-31, LncHIFCAR |
| Region | GRCh38_9:21455642-21559669 |
| Ensemble | ENSG00000171889 |
| Refseq | NR_027054 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | breast cancer |
| ICD-0-3 | C50 |
| Methods | qPCR, RNAi, Western blot etc. |
| Sample | breast cancer tissues, cell lines (MDA-MB-231, MDA-MB-435S etc.) |
| Expression Pattern | up-regulated |
| Function Description | We assay the expression level of lncRNAs-Loc554202 in breast cancer tissues and find that Loc554202 is significantly increased compared with normal control, and associated with advanced pathologic stage and tumor size. Moreover, knockdown of Loc554202 decreased breast cancer cell proliferation, induced apoptosis and inhibits migration/invasion in vitro and impeded tumorigenesis in vivo. |
| Pubmed ID | 24631686 |
| Year | 2014 |
| Title | Long non-coding RNA Loc554202 regulates proliferation and migration in breast cancer cells |
External Links
| Links for LOC554202 | GenBank HGNC NONCODE |
| Links for breast cancer | OMIM COSMIC |