Basic Information
| LncRNA/CircRNA Name | LOC554202 |
| Synonyms | MIR31HG, hsa-lnc-31, LncHIFCAR |
| Region | GRCh38_9:21455642-21559669 |
| Ensemble | ENSG00000171889 |
| Refseq | NR_027054 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | cervical cancer |
| ICD-0-3 | C53 |
| Methods | qPCR, Western blot etc. |
| Sample | cervical tissues |
| Expression Pattern | up-regulated |
| Function Description | Loc554202 is an independent poor prognostic factor through multivariate analysis. Subsequently, using cervical cancer cell lines, HeLa and ME-180, we decreased the expression levels of Loc554202 with siRNA. As results, the proliferation ability of cervical cancer cells was inhibited and apoptosis was induced after Loc554202 knockdown, as judged by viability assay, colony formation, and flow cytometry. Moreover, knockdown of Loc554202 expression downregulated Bcl-2 expression and conversely up-regulated Bax expression in cervical cancer cells using Western blotting analysis. In conclusion, elevated levels of Loc554202 are predictive of poor prognosis in cervical cancer. We suggest that Loc554202 may serve as a potential therapeutic target for cervical cancer. |
| Pubmed ID | 29129878 |
| Year | 2017 |
| Title | Elevated Expression Levels of Long Non-Coding RNA, Loc554202, Are Predictive of Poor Prognosis in Cervical Cancer |
External Links
| Links for LOC554202 | GenBank HGNC NONCODE |
| Links for cervical cancer | OMIM COSMIC |