Basic Information
| LncRNA/CircRNA Name | ASMTL-AS1 |
| Synonyms | ASMTL antisense RNA 1 |
| Region | GRCh38_X:1401769-1414028 |
| Ensemble | ENSG00000236017 |
| Refseq | XR_040863 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | papillary thyroid cancer |
| ICD-0-3 | NA |
| Methods | qRTPCR, RIP, Western blot, Luciferase reporter assay |
| Sample | PTC tissue samples and cell lines(Nthy-ori 3-1,K1, SW1736 and TPC1) |
| Expression Pattern | down-regulated |
| Function Description | Overexpression of ASMTL-AS1 evidently inhibited PTC cell proliferation and glycolysis, while knockdown of ASMTL-AS1 resulted in the opposite effect. Regarding the mechanism, ASMTL-AS1 was capable of sponging miR-93-3p and miR-660 to elevate FOXO1 expression, leading to repressing glycolysis and tumorigenesis. ASMTL-AS1 functions as a novel tumor suppressor in PTC through regulation of miR-93-3p/miR-660/FOXO1 pathway. |
| Pubmed ID | 31953163 |
| Year | 2020 |
| Title | Long Non-Coding RNA ASMTL-AS1 Inhibits Tumor Growth and Glycolysis by Regulating the miR-93-3p/miR-660/FOXO1 Axis in Papillary Thyroid Carcinoma |
External Links
| Links for ASMTL-AS1 | GenBank HGNC NONCODE |
| Links for papillary thyroid cancer | OMIM COSMIC |