Basic Information
| LncRNA/CircRNA Name | LOC400891 |
| Synonyms | LRRC74B |
| Region | GRCh38_22:21045960-21064168 |
| Ensemble | ENSG00000187905 |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | prostate cancer |
| ICD-0-3 | C61.9 |
| Methods | qPCR, RNAi, Western blot, Cell proliferation assay etc. |
| Sample | prostate cancer tissues, cell lines (PC-3, DU-145, 22RV1) |
| Expression Pattern | up-regulated |
| Function Description | We found that the expression level of LOC400891 was higher in PCa tissues and cells compared to adjacent non-tumor tissues and normal prostate stromal immortalized cells WPMY-1. The patients with higher LOC400891 expression had an advanced clinical features and a shorter biochemical recurrence-free survival time than those with lower LOC400891 expression. We also found that knockdown of LOC400891 could inhibit cell proliferation, migration, and invasion in vitro study. |
| Pubmed ID | 26797783 |
| Year | 2016 |
| Title | Overexpression of long non-coding RNA LOC400891 promotes tumor progression and poor prognosis in prostate cancer. |
External Links
| Links for LOC400891 | GenBank HGNC NONCODE |
| Links for prostate cancer | OMIM COSMIC |