Basic Information
| LncRNA/CircRNA Name | LOC285194 |
| Synonyms | TUSC7, LINC00902, LSAMP-AS1, LSAMP-AS3, LSAMPAS3, NCRNA00295 |
| Region | GRCh38_3:116709235-116723581 |
| Ensemble | ENSG00000243197 |
| Refseq | NR_015391 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | non small cell lung cancer |
| ICD-0-3 | C34 |
| Methods | qPCR, RNAi, Western blot, ChIP, Luciferase reporter assay, Cell proliferation assay, ISH etc. |
| Sample | cell lines (MCF-7, HCT-8, A549, HCT-116) |
| Expression Pattern | differential expression |
| Function Description | To further confirm the specific effect of p53 on loc285194 expression, we treated HCT-116 p53 null (HCT-116 null) cells at the same concentration of doxo. Although doxo also induced loc285294 in HCT-116 null cells, the level of induction was much lower than that in HCT-116-WT cells. Next, we examined loc285294 expression using a different set of primers derived from a different region of loc285194, further confirming this p53-mediated induction. In addition, such induction was also detected in other cell lines expressing wild-type p53, i.e. MCF-7, HCT-8 and A549 with 8-, 5- and 7-fold, respectively |
| Pubmed ID | 23558749 |
| Year | 2013 |
| Title | LncRNA loc285194 is a p53-regulated tumor suppressor. |
External Links
| Links for LOC285194 | GenBank HGNC NONCODE |
| Links for non small cell lung cancer | OMIM COSMIC |