Basic Information
| LncRNA/CircRNA Name | LOC285194 |
| Synonyms | TUSC7, LINC00902, LSAMP-AS1, LSAMP-AS3, LSAMPAS3, NCRNA00295 |
| Region | GRCh38_3:116709235-116723581 |
| Ensemble | ENSG00000243197 |
| Refseq | NR_015391 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colon cancer |
| ICD-0-3 | C18 |
| Methods | qPCR, RNAi, Western blot, ChIP, Luciferase reporter assay, Cell proliferation assay, ISH etc. |
| Sample | cell lines (MCF-7, HCT-8, A549, HCT-116) |
| Expression Pattern | differential expression |
| Function Description | To evaluate the biological consequence of p53 induction of loc285194 and the role of loc285194 in tumorigenesis, we ectopically expressed loc285194 in HCT-116 WT and MCF-7 cells for cell proliferation assays. As expected, loc285194 significantly inhibited tumor cell growth. |
| Pubmed ID | 23558749 |
| Year | 2013 |
| Title | LncRNA loc285194 is a p53-regulated tumor suppressor. |
External Links
| Links for LOC285194 | GenBank HGNC NONCODE |
| Links for colon cancer | OMIM COSMIC |