Basic Information
| LncRNA/CircRNA Name | loc285194 |
| Synonyms | TUSC7, LINC00902, LSAMP-AS1, LSAMP-AS3, LSAMPAS3, NCRNA00295 |
| Region | GRCh38_3:116709235-116723581 |
| Ensemble | ENSG00000243197 |
| Refseq | NR_015391 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | cervical squamous cell carcinoma |
| ICD-0-3 | C53 |
| Methods | qPCR, Western blot etc |
| Sample | CSCC biopsy tissue,cell lines (SiHa, C33A Manassas) |
| Expression Pattern | up-regulated |
| Function Description | RESULTS Expression of lncRNA loc285194 was downregulated in HPV-positive and HPV-negative tissue samples and plasma from patients with CSCC and distinguished between patients and healthy controls. Plasma levels of loc285194 and TGF-?1 were significantly correlated with the presence of CSCC. In SiHa and C33A cells, TGF-?1 expression was downregulated, and cell migration was inhibited following lncRNA loc285194 overexpression. Although lncRNA loc285194 expression was not affected by TGF-?1 treatment, its effects on cell migration were reduced by TGF-?1. |
| Pubmed ID | 31774069 |
| Year | 2019 |
| Title | Long Noncoding RNA loc285194 Expression in Human Papillomavirus-Positive and -Negative Cervical Squamous Cell Carcinoma, C33A, and SiHa Cells and Transforming Growth Factor-?1 |
External Links
| Links for loc285194 | GenBank HGNC NONCODE |
| Links for cervical squamous cell carcinoma | OMIM COSMIC |