Basic Information
| LncRNA/CircRNA Name | LOC284454 |
| Synonyms | NA |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | breast cancer |
| ICD-0-3 | C50 |
| Methods | RNA-seq, RT-qPCR, Western blot, in vitro knockdown, RIP |
| Sample | breast cancer tumor tissue, breast carcinoma cell lines (T47D and MCF7) |
| Expression Pattern | down-regulated |
| Function Description | Expression of LOC284454 is significantly reduced in breast, prostate, uterus and kidney cancer and also in breast cancer cell lines (MCF7 and T47D). Global gene expression studies upon loss and gain of function of LOC284454 revealed perturbation of genes related to cancer-related pathways. Focal adhesion and cell migration pathway genes are downregulated under overexpression condition, and these genes are significantly upregulated in breast cancer cell lines as well as breast cancer tissue samples suggesting a functional role of LOC284454 lncRNA in breast cancer pathobiology. |
| Pubmed ID | 29227193 |
| Year | 2017 |
| Title | DDX5/p68 associated lncRNA LOC284454 is differentially expressed in human cancers and modulates gene expression. |
External Links
| Links for LOC284454 | GenBank HGNC NONCODE |
| Links for breast cancer | OMIM COSMIC |