Basic Information
| LncRNA/CircRNA Name | LOC284454 |
| Synonyms | CTD-3252C9.4, LOC284454 |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | nasopharyngeal cancer |
| ICD-0-3 | C11 |
| Methods | Western blot, Microarray, qPCR, other |
| Sample | NPC tissues and cell lines (5-8F, HNE2, NP69, HNE1, and HK1) |
| Expression Pattern | up-regulated |
| Function Description | One lncRNA, LOC284454, was upregulated and associated with poor prognosis in NPC. In in vivo and in vitro assays, LOC284454 promoted the migration and invasion capacity of NPC cells. Mass spectrometry combined with bioinformatics suggested that LOC284454 affected the cytoskeletal and adhesion-related Rho/Rac signaling pathways. LOC284454 may be a potential novel treatment target and is expected to be a new diagnostic and prognostic marker in patients with NPC. |
| Pubmed ID | 30380023 |
| Year | 2019 |
| Title | Long non-coding RNA LOC284454 promotes migration and invasion of nasopharyngeal carcinoma via modulating the Rho/Rac signaling pathway. |
External Links
| Links for LOC284454 | GenBank HGNC NONCODE |
| Links for nasopharyngeal cancer | OMIM COSMIC |