Basic Information
| LncRNA/CircRNA Name | LOC146880 |
| Synonyms | ARHGAP27P1 |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | autophagy0 | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | non small cell lung cancer |
| ICD-0-3 | C34 |
| Methods | Microarray, qPCR, Western blot, Luciferase reporter assay etc. |
| Sample | NSCLC tissues, cell lines (A549, H1299, H1975 and PC9) |
| Expression Pattern | up-regulated |
| Function Description | Two of the lncRNAs, LOC146880 and ENST00000439577, were positively correlated with expression of two cancer-related genes, KPNA2 and RCC2, respectively. High expression of LOC146880 and ENST00000439577 were also associated with poor survival. Analysis of lncRNA expression in relation to DNA methylation showed that LOC146880 expression was down-regulated by DNA methylation in its promoter. Lowering the expression of LOC146880 or ENST00000439577 in tumor cells could inhibit cell proliferation, invasion and migration. |
| Pubmed ID | 27849024 |
| Year | 2016 |
| Title | Analysis of Microarray Data on Gene Expression and Methylation to Identify Long Non-coding RNAs in Non-small Cell Lung Cancer. |
External Links
| Links for LOC146880 | GenBank HGNC NONCODE |
| Links for non small cell lung cancer | OMIM COSMIC |