Basic Information
| LncRNA/CircRNA Name | LOC105372579 |
| Synonyms | NA |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | hepatocellular carcinoma |
| ICD-0-3 | C22.0 |
| Methods | qRT-PCR , Luciferase reporter assay, in vitro knockdown etc. |
| Sample | HCC and their adjacent normal tissues?,HCC cell lines (SMCC7721, HepG2, Hep3B, and Huh7) and normal liver cell line (LO2) |
| Expression Pattern | up-regulated |
| Function Description | LOC105372579 was highly expressed in HCC tissues and cell lines. Moreover, upregulated levels of LOC105372579 predicted poor prognosis.LOC105372579 silencing suppressed the proliferation of HCC cells in vitro. LOC105372579 knockdown inhibited the migration, invasion, and epithelial-mesenchymal transition of HCC cells.LOC105372579 promotes tumor growth in vivo.LOC105372579 is a sponge for miR-4316 and that FOXP4 is a direct target of miR-4316. |
| Pubmed ID | 31114338 |
| Year | 2019 |
| Title | LncRNA LOC105372579 Promotes Proliferation and Epithelial-Mesenchymal Transition in Hepatocellular Carcinoma via Activating miR-4316/FOXP4 Signaling |
External Links
| Links for LOC105372579 | GenBank HGNC NONCODE |
| Links for hepatocellular carcinoma | OMIM COSMIC |