Basic Information
| LncRNA/CircRNA Name | LOC101928316 |
| Synonyms | NA |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | qPCR, Western blot |
| Sample | The human GC cell lines including MKN-28, BGC-823, SGC-7901, MGC-803, and MKN-45, and the human normal gastric epithelium cell line (GES-1), GC tumor and paired non-tumor tissue |
| Expression Pattern | down-regulated |
| Function Description | LOC101928316 was significantly downregulated in gastric cancer (GC) tissues specimen, GC cell lines, and associated with the GC patients tumor, node, and metastasis (TNM) stage and degree of differentiation (P ??0.05). LOC101928316 overexpression can significantly inhibit SGC-7901 cell migration, invasion, and proliferation (P??.05). LOC101928316 molecular mechanism investigates suggested that LOC101928316 can regulate PI3K-Akt-mTOR signaling pathway and change the GC development progression in vivo and in vitro. In vivo experiment also revealed that LOC101928316-Overexpression can inhibit the tumorigenicity of GC cells in tumor-burdened experimental nude mice (P ??0.05). LOC101928316 may function as anti-oncogene and also plays an important role in GC tumorigenesis. |
| Pubmed ID | 31207155 |
| Year | 2019 |
| Title | LncRNA-LOC101928316 contributes to gastric cancer progression through regulating PI3K-Akt-mTOR signaling pathway |
External Links
| Links for LOC101928316 | GenBank HGNC NONCODE |
| Links for gastric cancer | OMIM COSMIC |