Basic Information
| LncRNA/CircRNA Name | LOC100507661 |
| Synonyms | LINC02082 |
| Region | GRCh38_3:168903366-168921996 |
| Ensemble | ENSG00000242268 |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | thyroid cancer |
| ICD-0-3 | C73.9 |
| Methods | qPCR etc. |
| Sample | cell lines (HEK293T, HEK293FT, FTC133, TPC1 etc.) |
| Expression Pattern | up-regulated |
| Function Description | LOC100507661, was strongly upregulated in thyroid cancer tissues relative to paired contralateral normal tissue. LOC100507661 was easily detectable in papillary and anaplastic thyroid cancer cell lines such as TPC1, BCPAP, C643, and 8505C, but not in the follicular thyroid cancer cell line FTC133. Stable overexpression of LOC100507661 promoted cell proliferation, migration, and invasion of thyroid cancer cells. Lymph node metastasis and BRAF V600E mutations were more frequent in papillary thyroid cancers with high LOC100507661 expression. |
| Pubmed ID | 27151833 |
| Year | 2016 |
| Title | Upregulation of long noncoding RNA LOC100507661 promotes tumor aggressiveness in thyroid cancer |
External Links
| Links for LOC100507661 | GenBank HGNC NONCODE |
| Links for thyroid cancer | OMIM COSMIC |