Basic Information
| LncRNA/CircRNA Name | 7SL |
| Synonyms | RN7SL1, 7L1a, 7SL, RN7SL, RNSRP1 |
| Region | GRCh38_14:49586580-49586878 |
| Ensemble | ENSG00000276168 |
| Refseq | NR_002715 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | breast cancer |
| ICD-0-3 | C50 |
| Methods | qPCR, Western blot, ChIP, Luciferase reporter assay etc. |
| Sample | cell lines (MCF-10A, MCF-7, HeLa, and HCT-116) |
| Expression Pattern | differential expression |
| Function Description | In this study, we detected that over-expression of FOXP3 repressed the transcription of 7SL RNA and contributed to inhibiting tumor growth. Knock down of FOXP3 in MCF-10A normal mammary breast cells up-regulated the transcription of 7SL RNA. Chromatin Immuno-precipitation (ChIP) analysis showed that FOXP3 directly bound to the Forkhead/HNF-3 domain DNA binding sites (-789 to -795) relative to the transcription start site. Meanwhile, Luciferase analysis showed that FOXP3 repressed the full-length 7SL promoter activity, but this suppressive effect was reversed after mutation of the FOXP3 binding site. Further studies showed that FOXP3 promoted the expression of P53 at translational levels through repressing 7SL RNA. |
| Pubmed ID | 26718402 |
| Year | 2016 |
| Title | Tumor FOXP3 represses the expression of long noncoding RNA 7SL. |
External Links
| Links for 7SL | GenBank HGNC NONCODE |
| Links for breast cancer | OMIM COSMIC |