Basic Information
| LncRNA/CircRNA Name | LOC100130476 |
| Synonyms | RP11-356I2.4, LOC100130476 |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | esophageal squamous cell carcinoma |
| ICD-0-3 | NA |
| Methods | qPCR, Luciferase reporter assay, Cell proliferation assay etc. |
| Sample | primary ESCC tissues, cell lines (cell lines TE1, TE13, T.Tn, Eca109 etc.) |
| Expression Pattern | down-regulated |
| Function Description | Significant downregulation of LOC100130476 was detected in esophageal cancer cell lines and primary ESCC tumor tissues. Up-regulation of LOC100130476 led to the inhibition of proliferation and invasiveness of the cancer cells. |
| Pubmed ID | 27338851 |
| Year | 2016 |
| Title | Aberrant methylation-mediated downregulation of long noncoding RNA LOC100130476 correlates with malignant progression of esophageal squamous cell carcinoma. |
External Links
| Links for LOC100130476 | GenBank HGNC NONCODE |
| Links for esophageal squamous cell carcinoma | OMIM COSMIC |