Basic Information
| LncRNA/CircRNA Name | LOC100129940-N |
| Synonyms | NA |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | papillary thyroid cancer |
| ICD-0-3 | NA |
| Methods | qRT-PCR, Western blotting etc. |
| Sample | KTC1 and TPC1 cell lines, 59 cases of fresh PTC and 11 pairs of fresh PTC and their matching noncancerous tissues |
| Expression Pattern | up-regulated |
| Function Description | The expression level of LOC100129940-N was elevated in PTC, indicating that LOC100129940-N may be involved in PTC development and progression. Moreover, our results showed that overexpression of LOC100129940-N promoted, whereas silencing of LOC100129940-N suppressed, PTC cell proliferation, invasion, and migration. Mechanistically, LOC100129940-N played an important role in activating Wnt/?-catenin signaling and upregulating downstream target genes. |
| Pubmed ID | 31093280 |
| Year | 2019 |
| Title | Long Noncoding RNA LOC100129940-N Is Upregulated in Papillary Thyroid Cancer and Promotes the Invasion and Progression |
External Links
| Links for LOC100129940-N | GenBank HGNC NONCODE |
| Links for papillary thyroid cancer | OMIM COSMIC |