Basic Information
| LncRNA/CircRNA Name | LOC100129148 |
| Synonyms | LOC100129148 |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | nasopharyngeal cancer |
| ICD-0-3 | C11 |
| Methods | qPCR, RNAi, Western blot, Luciferase reporter assay, CCK-8 assay etc. |
| Sample | NPC tissues, cell lines (SUNE-1, CNE-1, HNE-1, CNE-2, C666-1 and HONE-1) |
| Expression Pattern | up-regulated |
| Function Description | LOC100129148 was up-regulated in NPC tissues and cell lines, and higher expression of LOC100129148 resulted in a markedly poorer survival time.Over-expressed LOC100129148 favored, but silenced LOC100129148 hampered cell proliferation in NPC cells. Additionally, LOC100129148 enhanced the KLF12 expression through functioning as a competitive 'sponge' for miR-539-5p. |
| Pubmed ID | 28328537 |
| Year | 2017 |
| Title | Long non-coding RNA LOC100129148 functions as an oncogene in human nasopharyngeal carcinoma by targeting miR-539-5p. |
External Links
| Links for LOC100129148 | GenBank HGNC NONCODE |
| Links for nasopharyngeal cancer | OMIM COSMIC |