Basic Information
| LncRNA/CircRNA Name | lnPTENP1 |
| Synonyms | NA |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | osteosarcoma |
| ICD-0-3 | NA |
| Methods | qPCR, Western blot |
| Sample | osteosarcoma cell lines (Mg63 and SAOS2) |
| Expression Pattern | down-regulated |
| Function Description | The PTEN and lnPTENP1 mRNA expression levels were significantly downregulated in osteosarcoma cells compared with normal osteocytes. lnPTENP1 transfection significantly inhibited osteosarcoma cell growth, proliferation, migration and invasion. LnPTENP1 transfection also significantly promoted apoptosis in Mg63 cells treated with tunicamycin. Further analysis revealed that lnPTENP1 transfection regulated osteosarcoma cell growth via the PI3K/AKT signaling pathway. In vivo assays revealed that lnPTENP1 transfection significantly inhibited osteosarcoma tumor growth and significantly increased the protein expression and phosphorylation levels of PI3K and AKT. |
| Pubmed ID | 29805503 |
| Year | 2018 |
| Title | Long Non-Coding RNA Phosphatase and Tensin Homolog Pseudogene 1 Suppresses Osteosarcoma Cell Growth via the Phosphoinositide 3-kinase/protein Kinase B Signaling Pathway |
External Links
| Links for lnPTENP1 | GenBank HGNC NONCODE |
| Links for osteosarcoma | OMIM COSMIC |