Basic Information
| LncRNA/CircRNA Name | LNMAT1 |
| Synonyms | NA |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | Malignant Melanoma |
| ICD-0-3 | NA |
| Methods | qPCR, Western blot, RIP |
| Sample | Human malignant melanoma cell lines WM35, A375, A2058, and mouse malignant melanoma cell line B16/F10, human MM tissues, benign nevi (BN) tissues |
| Expression Pattern | up-regulated |
| Function Description | LNMAT1 was upregulated in MM tissues and cells, and its expression levels were further enhanced in MM patients with lymph node metastasis and metastatic MM cells. Using loss-of-function assays, we found that LNMAT1 promoted cell migration and invasion and lung metastasis in MM in vitro and in vivo. Moreover, we found that cell adhesion molecule 1 (CADM1), the established tumor suppressor in MM, was the downstream target of LNMAT1. Mechanistically, LNMAT1 epigenetically suppressed CADM1 expression by recruiting EZH2, the key regulator of trimethylation of histone H3 at lysine 27 (H3K27me3), to the CADM1 promoter, resulting in transcriptional inhibition of CADM1. Lastly, rescue assays demonstrated that LNMAT1 promoted cell migration and invasion of MM by suppressing CADM1 expression. |
| Pubmed ID | 31334110 |
| Year | 2019 |
| Title | LNMAT1 Promotes Invasion-Metastasis Cascade in Malignant Melanoma by Epigenetically Suppressing CADM1 Expression |
External Links
| Links for LNMAT1 | GenBank HGNC NONCODE |
| Links for Malignant Melanoma | OMIM COSMIC |