Basic Information
| LncRNA/CircRNA Name | lncZic2 |
| Synonyms | NA |
| Region | GRCh38_13:99981772-99986773 |
| Ensemble | ENSG00000043355 |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | liver cancer |
| ICD-0-3 | C22.0 |
| Methods | qPCR, Western blot, in vitro knockdown etc. |
| Sample | liver cancer tissues |
| Expression Pattern | up-regulated |
| Function Description | LncZic2 is required for the self-renewal of liver TICs in a ZIC2-independent manner. LncZic2 drove the expression of myristoylated alanine-rich protein kinase C substrate (MARCKS) and MARCKS-like 1 (MARCKSL1), whose expression levels were increased during liver tumorigenesis and liver TIC self-renewal. Mechanistically, lncZic2 interacted with BRM/SWI2-related gene 1 (BRG1) and recruited this transcriptional regulator to the promoters of the MARCKS and MARCKSL1 gene, which activated expression of these genes. Moreover, we noted that depletion of lncZic2 and BRG1 decreases MARCKS and MARCKSL1 expression and diminishes liver TIC levels. In conclusion, LncZic2 is required for the self-renewal of liver TICs by up-regulating MARCKS and MARCKSL1 gene expression via the transcription factor BRG1. |
| Pubmed ID | 29588366 |
| Year | 2018 |
| Title | The long noncoding RNA lncZic2 drives the self-renewal of liver tumor-initiating cells via the protein kinase C substrates MARCKS and MARCKSL1. |
External Links
| Links for lncZic2 | GenBank HGNC NONCODE |
| Links for liver cancer | OMIM COSMIC |