Basic Information
| LncRNA/CircRNA Name | lncWDR26 |
| Synonyms | NA |
| Region | GRCh38_1:224385143-224437033 |
| Ensemble | ENSG00000162923 |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | hepatocellular carcinoma |
| ICD-0-3 | C22.0 |
| Methods | qPCR, Western blot, in vitro knockdown etc. |
| Sample | cell lines (SMMC-7721, PLC/PRF/5, Huh7, SK-Hep-1 and Hep3B, LO2), HCC tissue |
| Expression Pattern | down-regulated |
| Function Description | lncWDR26 was significantly downregulated in HCC tissues and cells. Moreover, decreased lncWDR26 expression correlates with larger tumor size, higher clinical stage, and tumor metastasis, and also predicts poor prognosis in patients with HCC. In HCC cells, overexpression of lncWDR26 inhibited growth and metastasis, both in vitro and in vivo. Mechanistically, lncWDR26 suppressed HCC growth and metastasis by inhibiting WDR26 transcription. Notably, lncWDR26 was associated with SIX homeobox 3 (SIX3), and this association was required for the repression of WDR26 transcription. |
| Pubmed ID | 29736313 |
| Year | 2018 |
| Title | A novel long noncoding RNA lncWDR26 suppresses the growth and metastasis of hepatocellular carcinoma cells through interaction with SIX3. |
External Links
| Links for lncWDR26 | GenBank HGNC NONCODE |
| Links for hepatocellular carcinoma | OMIM COSMIC |