Basic Information
| LncRNA/CircRNA Name | lncTIC1 |
| Synonyms | NA |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | liver cancer |
| ICD-0-3 | C22.0 |
| Methods | qPCR, Western blot, in vitro knockdown, RIP |
| Sample | liver cancer tissues |
| Expression Pattern | up-regulated |
| Function Description | LncTIC1 was highly expressed with liver tumorigenesis. Meanwhile, lncTIC1 expression levels were related to liver cancer relapse, metastasis and clinical prognosis. LncTIC1 was also highly expressed in liver TICs and required for the self-renewal of liver TICs. LncTIC1 drove liver TIC self-renewal through Wnt/?-catenin signaling. LncTIC1 interacted with the N terminal of ?-catenin and inhibited the phosphorylation of ?-catenin, finally maintaining the stability of ?-catenin to drive the activation of Wnt/?-catenin signaling. Through ?-catenin maintenance and Wnt/?-catenin regulation, lncTIC1 participated in liver TIC self-renewal, liver tumorigenesis and tumor propagation. Moreover, blockade of lncTIC1 signaling greatly inhibited the propagation of liver cancer and liver TICs. |
| Pubmed ID | 29778568 |
| Year | 2018 |
| Title | LncTIC1 Interacts With ?-Catenin to Drive Liver TIC Self-Renewal and Liver Tumorigenesis |
External Links
| Links for lncTIC1 | GenBank HGNC NONCODE |
| Links for liver cancer | OMIM COSMIC |