Basic Information
| LncRNA/CircRNA Name | lncTCF7 |
| Synonyms | WSPAR, LncTCF7, TCONS_00009511, NR_033449 |
| Region | GRCh38_5:134114711-134151865 |
| Ensemble | ENSG00000081059 |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colorectal cancer |
| ICD-0-3 | C19.9 |
| Methods | qPCR, Western blot |
| Sample | colorectal cancer tissues, cell lines (DLD1 and LoVo) |
| Expression Pattern | up-regulated |
| Function Description | LncTCF7 was upregulated in 52/58 CRC tissues, and its expression correlated with tumor size, lymph metastasis and tumor-node-metastasis stage in CRC. Knocking down lncTCF7 in colon cancer cell lines decreased cell proliferation, migration and invasion.lncTCF7 promoted cell proliferation in vivo. LncTCF7 activated the Wnt/B-catenin signaling pathway,which is essential for cancer development.patients with higher expression of lncTCF7 had significantly worse prognosis compared with patients with low expression. |
| Pubmed ID | 29344178 |
| Year | 2017 |
| Title | Long non-coding RNA lncTCF7 activates the Wnt/B-catenin pathway to promote metastasis and invasion in colorectal cancer. |
External Links
| Links for lncTCF7 | GenBank HGNC NONCODE |
| Links for colorectal cancer | OMIM COSMIC |