Basic Information
| LncRNA/CircRNA Name | lncTCF7 |
| Synonyms | WSPAR, LncTCF7, TCONS_00009511, NR_033449 |
| Region | GRCh38_5:134114711-134151865 |
| Ensemble | ENSG00000081059 |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | IL-6 | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | glioma |
| ICD-0-3 | NA |
| Methods | qPCR, in vitro knockdown |
| Sample | glioma tissues |
| Expression Pattern | up-regulated |
| Function Description | lncTCF7 was significantly associated with WHO grade and tumour size.patients with high lncTCF7 expression levels exhibited markedly worse overall survival prognoses. knockdown of lncTCF7 significantly inhibited glioma cell migration, proliferation and tumorigenicity in vitro and in vivo. hypoxia induced lncTCF7 expression in an autocrine manner through IL-6 in glioma. |
| Pubmed ID | 29234033 |
| Year | 2017 |
| Title | lncTCF7 is a negative prognostic factor, and knockdown of lncTCF7 inhibits migration, proliferation and tumorigenicity in glioma. |
External Links
| Links for lncTCF7 | GenBank HGNC NONCODE |
| Links for glioma | OMIM COSMIC |