Basic Information
| LncRNA/CircRNA Name | lncSOX4 |
| Synonyms | NA |
| Region | GRCh38_6:21592768-21598619 |
| Ensemble | ENSG00000124766 |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | epithelial ovarian cancer |
| ICD-0-3 | C56.9 |
| Methods | qPCR, Western blot etc. |
| Sample | ovarian tissues, cell lines (EOC and IOSE-80) |
| Expression Pattern | up-regulated |
| Function Description | The results demonstrated that the LncSOX4 expression level was significantly upregulated in epithelial ovarian cancer tissues (3.98 vs. 1.71, P<0.001). Silencing LncSOX4 in the SKOV3 and OVCAR3 cell lines significantly impaired cell proliferation (P<0.001). Cell cycle assays revealed that the proportion of cells in the G0/G1 phase increased significantly, whereas those in the S phase and G2/M phase decreased. Apoptosis rate additionally increased following knockdown of LncSOX4 in the two cell lines. Furthermore, it was observed that an increased LncSOX4 expression level was positively associated with larger tumor sizes, more advanced tumor grade and more distant metastases. |
| Pubmed ID | 29693704 |
| Year | 2018 |
| Title | LncSOX4 serves an oncogenic role in the tumorigenesis of epithelial ovarian cancer by promoting cell proliferation and inhibiting apoptosis. |
External Links
| Links for lncSOX4 | GenBank HGNC NONCODE |
| Links for epithelial ovarian cancer | OMIM COSMIC |