Basic Information
LncRNA/CircRNA Name | SNHG1 |
Synonyms | SNHG1, LINC00057, NCRNA00057, U22HG, UHG, lncRNA16 |
Region | GRCh38_11:62851988-62855914 |
Ensemble | ENSG00000255717 |
Refseq | NR_003098 |
Classification Information
Regulatory Mechanism | Biological Function | Clinical Application | |||
---|---|---|---|---|---|
TF | Immune | Survival | |||
Enhancer | Apoptosis | apoptosis | Drug | ||
Variant | Cell Growth | Circulating | 2 | ||
MiRNA | EMT | Metastasis | |||
Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
Cancer Name | pituitary cancer |
ICD-0-3 | NA |
Methods | qPCR, Western blot |
Sample | pituitary tumor tissues, cell lines(GH1, RC-4B/C) |
Expression Pattern | up-regulated |
Function Description | We found that lnc-SNHG1 was overexpressed in invasive pituitary tumor tissues and cell lines. Ectopic expression of lnc-SNHG1 promoted cell proliferation, migration, and invasion, as well as the epithelial-mesenchymal transition (EMT), by affecting the cell cycle and cell apoptosis in vitro and tumor growth in vivo. Further study indicated that overexpression of lnc-SNHG1 markedly inhibited the expression of miR-302/372/373/520 (miRNA-pool) which is down-regulated in invasive pituitary tumor cells. |
Pubmed ID | 30048990 |
Year | 2018 |
Title | Lnc-SNHG1 Activates the TGFBR2/SMAD3 and RAB11A/Wnt/?-Catenin Pathway by Sponging MiR-302/372/373/520 in Invasive Pituitary Tumors. |
External Links
Links for SNHG1 | GenBank HGNC NONCODE |
Links for pituitary cancer | OMIM COSMIC |