Basic Information
| LncRNA/CircRNA Name | lnc-SGK1 |
| Synonyms | SGK1, SGK |
| Region | GRCh38_6:134169246-134318112 |
| Ensemble | ENSG00000118515 |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | qPCR, Dual luciferase reporter assay, Immunohistochemistry etc. |
| Sample | GC tissues |
| Expression Pattern | up-regulated |
| Function Description | Within T cells, Helicobacter pylori (Hp) infection and high-salt dietcan up-regulated SGK1 expression and in turn enhance expression of Lnc-SGK1 through JunB activation. And expression of Lnc-SGK1 can further enhance transcription of SGK1 through cis regulatory mode. Lnc-SGK1 can induce Th2 and Th17 and reduce Th1 differentiation via SGK1/JunB signaling. Serum Lnc-SGK1 expression in combination with H. pylori infection and/or HSD in T cells was associated with poor prognosis of GC patients, and could be an ideal diagnostic index in human GC |
| Pubmed ID | 26942879 |
| Year | 2016 |
| Title | Lnc-SGK1 induced by Helicobacter pylori infection and highsalt diet promote Th2 and Th17 differentiation in human gastric cancer by SGK1/Jun B signaling. |
External Links
| Links for lnc-SGK1 | GenBank HGNC NONCODE |
| Links for gastric cancer | OMIM COSMIC |