Basic Information
| LncRNA/CircRNA Name | lnc-RTN4R-1 |
| Synonyms | NA |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | B-cell precursor acute lymphoblastic leukemia |
| ICD-0-3 | NA |
| Methods | RNA-seq, Microarray, qPCR, Western blot |
| Sample | bone marrow tissues, cell lines (REH, SEM, SUP-B15, NALM-6, NALM-19, RCH-ACV, RS4, 11, KASUMI-2, KOPN-8, MUTZ-5, MHH-CALL-2, MHH-CALL-3, MHH-CALL-4) |
| Expression Pattern | differential expression |
| Function Description | Next, integration of this lncRNA signature with RNA sequencing of BCP-ALL cell lines and lncRNA profiling of an in vitro model system of ETV6/RUNX1 knockdown, revealed that lnc-NKX2-3-1, lnc-TIMM21-5, lnc-ASTN1-1 and lnc-RTN4R-1 are truly regulated by the oncogenic fusion protein. |
| Pubmed ID | 27650541 |
| Year | 2016 |
| Title | Unique long non-coding RNA expression signature in ETV6/RUNX1-driven B-cell precursor acute lymphoblastic leukemia |
External Links
| Links for lnc-RTN4R-1 | GenBank HGNC NONCODE |
| Links for B-cell precursor acute lymphoblastic leukemia | OMIM COSMIC |