Basic Information
| LncRNA/CircRNA Name | lncRNA-ZNF281 |
| Synonyms | NA |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | glioma |
| ICD-0-3 | NA |
| Methods | qPCR, Western blot, etc. |
| Sample | brain glioma tissue, Glioma cell lines U251,Glioma stem- like cells (U251s) |
| Expression Pattern | down-regulated |
| Function Description | The expression of lncRNA-ZNF281 was lower in glioma stem-like cells (U251s) and this indicates that lncRNA-ZNF281 can regulate the self-renewal capacity of glioma stem-like cells and stem cell marker expression. Most significantly, lncRNA-ZNF281 inhibits the invasion of glioma stem-like cells by regulating the expression of the NF- B1 signaling pathway. Our data demonstrates that lncRNA-ZNF281 inhibits the self-renewing ability and invasion of GSCs in vitro and in vivo and can reduce tumorigenicity in the glioma stem-like cell (U251s). The underlying mechanisms may involve the regulation of stem cell markers (CD133, Nestin, OCT4 and Nanog) to reduce the self-renewal ability and regulate the NF- B1 signaling pathway and inhibit U251s glioma stem-like cell invasion. |
| Pubmed ID | 30509101 |
| Year | 2018 |
| Title | Novel lncRNA-ZNF281 regulates cell growth, stemness and invasion of glioma stem-like U251s cells. |
External Links
| Links for lncRNA-ZNF281 | GenBank HGNC NONCODE |
| Links for glioma | OMIM COSMIC |