Basic Information
| LncRNA/CircRNA Name | lncRNA-URHC |
| Synonyms | NA |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | hepatocellular carcinoma |
| ICD-0-3 | C22.0 |
| Methods | Microarray, qPCR, Western blot etc. |
| Sample | HCC tissues, cell lines (DMEM, Gibco, Gaithersburg, MD, USA etc.) |
| Expression Pattern | up-regulated |
| Function Description | We confirmed that URHC expression was up-regulated in 30 HCC cases (57.7%) and that its higher expression was correlated with poor overall survival. We further demonstrated that URHC inhibition reduced cell proliferation and promoted apoptosis. high URHC expression can promote cell proliferation and inhibit apoptosis by repressing ZAK expression through inactivation of the ERK/MAPK pathway. |
| Pubmed ID | 25013376 |
| Year | 2014 |
| Title | Long non-coding RNA URHC regulates cell proliferation and apoptosis via ZAK through the ERK/MAPK signaling pathway in hepatocellular carcinoma. |
External Links
| Links for lncRNA-URHC | GenBank HGNC NONCODE |
| Links for hepatocellular carcinoma | OMIM COSMIC |