Basic Information
| LncRNA/CircRNA Name | lncRNA-UNMIBC |
| Synonyms | NA |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | bladder cancer |
| ICD-0-3 | C67 |
| Methods | qPCR, Western blot, RIP, ChIP etc. |
| Sample | bladder cancer tissues, cell lines (J82, UM-UC-3, HT-1376, T24, 5637, TCCSUP etc.) |
| Expression Pattern | up-regulated |
| Function Description | The expression level of lncRNA-UNMIBC was up-regulated in the tissues of 45 cases of primary nonmuscle invasive bladder cancer compared with normal mucosa. We also found that lncRNA-UNMIBC had a key role in G0/G1 arrest. Furthermore, RNA and chromatin immunoprecipitation assays demonstrated that lncRNA-UNMIBC was physically associated with EZH2 and SUZ12, leading to an altered histone H3 lysine 27 methylation status of target genes. |
| Pubmed ID | 27267320 |
| Year | 2016 |
| Title | lncRNA Up-Regulated in Nonmuscle Invasive Bladder Cancer Facilitates Tumor Growth and Acts as a Negative Prognostic Factor of Recurrence. |
External Links
| Links for lncRNA-UNMIBC | GenBank HGNC NONCODE |
| Links for bladder cancer | OMIM COSMIC |